Louisville Cardinals vs Syracuse Orange prediction
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Last line before the game
| Moneyline | Louisville Cardinals -650 · Syracuse Orange +450 |
| Spread | Syracuse Orange +14.5 |
| Total | 55.5 |
Latest line across Bovada, Draft Kings.
Matchup
Louisville Cardinals visited Syracuse Orange at JMA Wireless Dome on Saturday, October 17, 2026 at 6:30 PM CT, on ACC Network.
Louisville Cardinals came in at 4-3; Syracuse Orange were 2-4.
On the moneyline the market favors Louisville Cardinals at -650, with Syracuse Orange at +450 — once the bookmaker margin is removed, that prices Louisville Cardinals at about 83% to win.
The spread has Syracuse Orange at +14.5 and Louisville Cardinals at -14.5.
That line has moved from Syracuse Orange +13.5 when we first tracked it.
The game total is 55.5.
The total has moved down from 56.5 since we first tracked it.
Final: Louisville Cardinals 34, Syracuse Orange 26. Louisville Cardinals won.
Our NCAAF record
| All-time | 14-17 (45%) · 1 push |
| This season (since Aug 1, 2026) | 14-17 (45%) |
| Last 14 days | 2-3 (40%) |
Win rate and record of every NCAAF pick sent to members on the current model, graded after the final whistle. Full track record →