SMU Mustangs vs Louisville Cardinals prediction
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Last line before the game
| Moneyline | SMU Mustangs -102 · Louisville Cardinals -118 |
| Spread | Louisville Cardinals -1.5 |
| Total | 58.5 |
Latest line across Draft Kings.
Matchup
No. 16 SMU Mustangs visited No. 23 Louisville Cardinals at L&N Federal Credit Union Stadium on Saturday, September 19, 2026 at 2:30 PM CT, on ESPN2.
SMU Mustangs came in at 2-1; Louisville Cardinals were 2-1.
On the moneyline the market favors Louisville Cardinals at -118, with SMU Mustangs at -102 — once the bookmaker margin is removed, that prices Louisville Cardinals at about 52% to win.
The spread has Louisville Cardinals at -1.5 and SMU Mustangs at +1.5.
The game total is 58.5.
Final: SMU Mustangs 31, Louisville Cardinals 41. Louisville Cardinals won.
Our NCAAF record
| All-time | 14-17 (45%) · 1 push |
| This season (since Aug 1, 2026) | 14-17 (45%) |
| Last 14 days | 2-3 (40%) |
Win rate and record of every NCAAF pick sent to members on the current model, graded after the final whistle. Full track record →