Arizona Cardinals vs San Francisco 49ers prediction
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Last line before the game
| Moneyline | Arizona Cardinals +285 · San Francisco 49ers -400 |
| Spread | San Francisco 49ers -7.5 |
| Total | 48 |
Latest line across Bovada, FanDuel.
Matchup
Arizona Cardinals visited San Francisco 49ers at Levi's Stadium on Sunday, September 27, 2026 at 3:05 PM CT, on FOX.
Arizona Cardinals came in at 1-2; San Francisco 49ers were 3-0.
On the moneyline the market favors San Francisco 49ers at -400, with Arizona Cardinals at +285 — once the bookmaker margin is removed, that prices San Francisco 49ers at about 75% to win.
The spread has San Francisco 49ers at -7.5 and Arizona Cardinals at +7.5.
That line has moved from San Francisco 49ers -8.5 when we first tracked it.
The game total is 48.
Final: Arizona Cardinals 30, San Francisco 49ers 36. San Francisco 49ers won.
Our NFL record
| All-time | 8-9 (47%) |
| This season (since Aug 1, 2026) | 8-9 (47%) |
| Last 14 days | 1-4 (20%) |
Win rate and record of every NFL pick sent to members on the current model, graded after the final whistle. Full track record →