Denver Broncos vs San Francisco 49ers prediction
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Last line before the game
| Moneyline | Denver Broncos +125 · San Francisco 49ers -152 |
| Spread | San Francisco 49ers -2.5 |
| Total | 48 |
Latest line across Bovada, FanDuel.
Matchup
Denver Broncos visited San Francisco 49ers at Levi's Stadium on Sunday, October 4, 2026 at 3:25 PM CT, on CBS.
Denver Broncos came in at 2-2; San Francisco 49ers were 4-0.
On the moneyline the market favors San Francisco 49ers at -152, with Denver Broncos at +125 — once the bookmaker margin is removed, that prices San Francisco 49ers at about 58% to win.
The spread has San Francisco 49ers at -2.5 and Denver Broncos at +2.5.
The game total is 48.
The total has moved down from 48.5 since we first tracked it.
Final: Denver Broncos 14, San Francisco 49ers 24. San Francisco 49ers won.
Our NFL record
| All-time | 8-9 (47%) |
| This season (since Aug 1, 2026) | 8-9 (47%) |
| Last 14 days | 1-4 (20%) |
Win rate and record of every NFL pick sent to members on the current model, graded after the final whistle. Full track record →