Detroit Lions vs Buffalo Bills prediction
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Last line before the game
| Moneyline | Detroit Lions +200 · Buffalo Bills -255 |
| Spread | Buffalo Bills -5.5 |
| Total | 54.5 |
Latest line across FanDuel, Bovada.
Matchup
Detroit Lions visited Buffalo Bills at Highmark Stadium on Thursday, September 17, 2026 at 7:15 PM CT, on Prime Video.
Detroit Lions came in at 1-1; Buffalo Bills were 2-0.
On the moneyline the market favors Buffalo Bills at -255, with Detroit Lions at +200 — once the bookmaker margin is removed, that prices Buffalo Bills at about 68% to win.
The spread has Buffalo Bills at -5.5 and Detroit Lions at +5.5.
That line has moved from Buffalo Bills -4.5 when we first tracked it.
The game total is 54.5.
Final: Detroit Lions 31, Buffalo Bills 41. Buffalo Bills won.
Our NFL record
| All-time | 8-9 (47%) |
| This season (since Aug 1, 2026) | 8-9 (47%) |
| Last 14 days | 1-4 (20%) |
Win rate and record of every NFL pick sent to members on the current model, graded after the final whistle. Full track record →