Los Angeles Chargers vs Buffalo Bills prediction
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Last line before the game
| Moneyline | Los Angeles Chargers -146 · Buffalo Bills -350 |
| Spread | Buffalo Bills -7.5 |
| Total | 45.5 |
Latest line across Bovada, FanDuel.
Matchup
Los Angeles Chargers visited Buffalo Bills at Highmark Stadium on Sunday, September 27, 2026 at 12:00 PM CT, on FOX.
Los Angeles Chargers came in at 0-3; Buffalo Bills were 3-0.
On the moneyline the market favors Buffalo Bills at -350, with Los Angeles Chargers at -146 — once the bookmaker margin is removed, that prices Buffalo Bills at about 57% to win.
The spread has Buffalo Bills at -7.5 and Los Angeles Chargers at +7.5.
The game total is 45.5.
The total has moved down from 50 since we first tracked it.
Final: Los Angeles Chargers 16, Buffalo Bills 24. Buffalo Bills won.
Our NFL record
| All-time | 8-9 (47%) |
| This season (since Aug 1, 2026) | 8-9 (47%) |
| Last 14 days | 1-4 (20%) |
Win rate and record of every NFL pick sent to members on the current model, graded after the final whistle. Full track record →