Miami Dolphins vs San Francisco 49ers prediction
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Last line before the game
| Moneyline | Miami Dolphins +660 · San Francisco 49ers -1200 |
| Spread | San Francisco 49ers -13.5 |
| Total | 45 |
Latest line across FanDuel, Bovada.
Matchup
Miami Dolphins visited San Francisco 49ers at Levi's Stadium on Sunday, September 20, 2026 at 3:25 PM CT, on FOX.
Miami Dolphins came in at 0-2; San Francisco 49ers were 2-0.
On the moneyline the market favors San Francisco 49ers at -1200, with Miami Dolphins at +660 — once the bookmaker margin is removed, that prices San Francisco 49ers at about 88% to win.
The spread has San Francisco 49ers at -13.5 and Miami Dolphins at +13.5.
The game total is 45.
The total has moved down from 45.5 since we first tracked it.
Final: Miami Dolphins 13, San Francisco 49ers 35. San Francisco 49ers won.
Our NFL record
| All-time | 8-9 (47%) |
| This season (since Aug 1, 2026) | 8-9 (47%) |
| Last 14 days | 1-4 (20%) |
Win rate and record of every NFL pick sent to members on the current model, graded after the final whistle. Full track record →